FoxO1 mediates odontoblast differentiation of hDPSCs via B cell‐derived ANGPTL1 in dental caries: A laboratory investigation
Our study reveals a novel mechanism in which ANGPTL1 secreted by B cells in a carious environment promotes the odontoblast differentiation of hDPSCs by upregulating FoxO1. This finding highlights a potential therapeutic target for enhancing dental pulp repair and regeneration.
Authors
- Peimeng Zhan (ORCID: https://orcid.org/0009-0007-2475-8384)
- Zhuo Xie (ORCID: https://orcid.org/0000-0002-0976-079X)
- Shuheng Huang (ORCID: https://orcid.org/0000-0001-8552-7319)
- Zhengmei Lin (ORCID: https://orcid.org/0000-0003-1586-3741)
- Huang Zhu (ORCID: https://orcid.org/0000-0002-9048-5499)
- Runfu Wang (ORCID: https://orcid.org/0009-0009-1583-1636)
- Zongshan Shen (ORCID: https://orcid.org/0000-0003-2652-3507)
- Xinfang Zhang (ORCID: https://orcid.org/0000-0001-7359-0695)
- Qiting Huang
- Ling‐Ling Chen (ORCID: https://orcid.org/0000-0002-3005-526X)
Institutions
- Stomatology Hospital (CN)
Publication Details
- Journal
- International Endodontic Journal
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1111/iej.14206
- Citations
- 4
- Primary Topic
- Lipid metabolism and disorders
- Type
- article
- Field-Weighted Citation Impact
- 5.55
Funders
- National Natural Science Foundation of China
- Science and Technology Planning Project of Guangdong Province