Causal association of sex hormone-related traits with Alzheimer’s disease: a multivariable and network Mendelian randomization analysis
Our study using the MR methodology indicates that increase of SHBG level and decrease of testosterone level in females are positively linked to an increased risk of developing AD. Importantly, testosterone plays a mediating role in the causal pathway from SHBG to females AD.
Authors
- Yu-Shen Yang (ORCID: https://orcid.org/0000-0003-0310-3999)
- Zhendong Sun (ORCID: https://orcid.org/0000-0003-2134-6652)
- Weidong Fu (ORCID: https://orcid.org/0009-0001-7814-478X)
- Yan Zhang (ORCID: https://orcid.org/0000-0003-4647-4853)
Institutions
- Fujian Medical University (CN)
- Central South University (CN)
- Second Affiliated Hospital of Fujian Medical University (CN)
- Zhuzhou Central Hospital (CN)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-02-05
- DOI
- https://doi.org/10.3389/fneur.2025.1391182
- Citations
- 1
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.82