Serotonin Regulates Lipogenesis and Endoplasmic Reticulum Stress in Alcoholic Liver Disease
GDS directly regulates lipogenesis and ER stress via signaling through hepatic HTR2A in the context of ALD. Inhibiting HTR2A signaling protects against alcohol-induced steatosis, liver injury and disease progression in various ALD mouse models and may also provide a novel therapeutic strategy for ALD.
Authors
- Hail Kim (ORCID: https://orcid.org/0000-0002-6652-1349)
- Jung Eun Nam (ORCID: https://orcid.org/0000-0002-7021-8406)
- Wonsuk Choi (ORCID: https://orcid.org/0000-0002-0523-0839)
- Won Gun Choi (ORCID: https://orcid.org/0000-0002-5628-5581)
- Inseon Hwang
- Young-Ah Moon (ORCID: https://orcid.org/0000-0002-4569-5817)
- Eunji Lee (ORCID: https://orcid.org/0000-0001-9403-6132)
- Jun Yong Park (ORCID: https://orcid.org/0000-0001-6324-2224)
- Hyeongseok Kim
Institutions
- Daejeon University (KR)
- Korea Advanced Institute of Science and Technology (KR)
- Inha University (KR)
- Yonsei University (KR)
- Chungnam National University (KR)
- Severance Hospital (KR)
- Gangnam Severance Hospital (KR)
- Chonnam National University Hwasun Hospital (KR)
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
- Daejeon Health Institute of Technology (KR)
- Catholic University of Korea (KR)
Publication Details
- Journal
- Diabetes & Metabolism Journal
- Published
- 2025-02-05
- DOI
- https://doi.org/10.4093/dmj.2024.0215
- Citations
- 2
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- National Research Foundation
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea