Myofibrillogenesis Regulator-1 in Smooth Muscle Cells Modulates Inflammation Signaling Pathways via Regulating ROCK1 Ubiquitination and Degradation to Impact Aortic Dissection
MR-1 and ROCK1 overexpression is associated with the occurrence and development of AD through inflammation. This study highlights the role of inflammation in AD development and tap the potentiality of using MR-1 and ROCK1 as targets to alleviate AD development.
Authors
- Chuanbao Li
- Xiaoxing Li (ORCID: https://orcid.org/0000-0001-8791-7505)
- Feng Xu (ORCID: https://orcid.org/0000-0003-4351-0222)
- Zeyu Yang (ORCID: https://orcid.org/0000-0002-7223-5234)
- Xin Zhao (ORCID: https://orcid.org/0000-0002-8178-4737)
- Dong Lü (ORCID: https://orcid.org/0000-0003-2856-1785)
- Yuguo Chen
- Hang Yin (ORCID: https://orcid.org/0000-0001-8687-1779)
- Zerui Wang (ORCID: https://orcid.org/0000-0003-1784-1079)
Institutions
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-02-01
- DOI
- https://doi.org/10.2147/jir.s485163
- Primary Topic
- Aortic Disease and Treatment Approaches
- Type
- article
- Field-Weighted Citation Impact
- 0.00