The <scp>miR</scp>‐6779/<scp>XIAP</scp> axis alleviates <scp>IL</scp>‐1β‐induced chondrocyte senescence and extracellular matrix loss in osteoarthritis
miR-6779 is down-regulated, and XIAP is up-regulated in OA cartilage and IL-1β-treated chondrocytes. miR-6779 inhibits XIAP expression, thereby promoting senescent chondrocyte cell apoptosis and reducing chondrocyte senescence and ECM loss through XIAP.
Authors
- Jingyue Su (ORCID: https://orcid.org/0000-0002-1369-0173)
- Aonan Dai
- Zhenhan Deng (ORCID: https://orcid.org/0000-0003-0522-8269)
- Xiao-Xiang Fang
- Shengwu Yang (ORCID: https://orcid.org/0000-0002-8398-8864)
- Xin Chen (ORCID: https://orcid.org/0000-0002-9588-0164)
- Liangjun Li (ORCID: https://orcid.org/0000-0003-2593-3440)
- Kun Chen (ORCID: https://orcid.org/0000-0002-8160-7300)
- Zongchao Li
- Peng Gao (ORCID: https://orcid.org/0009-0008-1896-5608)
- Kexing Tang
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Changsha Central Hospital (CN)
- University of South China (CN)
Publication Details
- Journal
- Animal Models and Experimental Medicine
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1002/ame2.12529
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wenzhou Medical University
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province
- Wenzhou Municipal Science and Technology Bureau