A pharmacoinformatic approach for studying Atractylodes Lancea DC’s anticancer potential and control ROS-mediated apoptosis against prostate cancer cells
These findings demonstrate that ALD exerts potent anticancer effects against metastatic prostate cancer cells through ROS-mediated apoptosis and mitochondrial dysfunction, while exhibiting minimal cytotoxicity toward normal prostate cells. The presence of ac-tive compounds such as Atractylenolide II and III suggests a synergistic interaction that enhances AR inhibition and promotes apoptosis. ALD's ability to engage multiple path-ways highlights its therapeutic potential as a selective and multifaceted treatment for ag-gressive prostate cancer.
Authors
- Jinwon Choi
- Kazi Rejvee Ahmed (ORCID: https://orcid.org/0000-0002-6273-0645)
- Abdel Halim Harrath (ORCID: https://orcid.org/0000-0002-2170-1303)
- Hwa‐Seung Yoo (ORCID: https://orcid.org/0000-0003-3738-3239)
- Md. Maharub Hossain Fahim (ORCID: https://orcid.org/0000-0003-4864-3833)
- Chi‐Hoon Ahn
- Mohammed Dalli (ORCID: https://orcid.org/0000-0002-0722-7414)
- K W Kim
- Moon Nyeo Park (ORCID: https://orcid.org/0000-0002-9276-3894)
- Rony Abdi Syahputra (ORCID: https://orcid.org/0000-0003-2016-0151)
- Md. Ataur Rahman (ORCID: https://orcid.org/0000-0001-6649-3694)
- Min Ji Choi (ORCID: https://orcid.org/0000-0002-5476-356X)
- Bonglee Kim (ORCID: https://orcid.org/0000-0002-8678-156X)
- Seungjoon Moon
- M M Rahman (ORCID: https://orcid.org/0000-0002-0118-4716)
- Sang‐Won Shin (ORCID: https://orcid.org/0000-0003-1426-4050)
- Ji Soo Myong
Institutions
- Daejeon University (KR)
- Wayne State University (US)
- Universitas Sumatera Utara (ID)
- King Saud University (SA)
- Kyung Hee University (KR)
- The Barbara Ann Karmanos Cancer Institute (US)
- Instituts Supérieurs des Professions Infirmières et Techniques de Santé (MA)
- Mohamed I University (MA)
- Pusan National University (KR)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-02-05
- DOI
- https://doi.org/10.3389/fonc.2025.1471110
- Citations
- 4
- Primary Topic
- Traditional Chinese Medicine Analysis
- Type
- article
- Field-Weighted Citation Impact
- 9.53
Funders
- National Research Foundation
- King Saud University
- Kyung Hee University
- Korea Health Industry Development Institute
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea