Exosomes secreted by ATF3/Nrf2-mediated ferroptotic renal tubular epithelial cells promote M1/M2 ratio imbalance inducing renal interstitial fibrosis following ischemia and reperfusion injury
ATF3 might accelerate the ferroptosis by inhibiting Nrf2/ARE pathway, and exosomes from ferroptotic cells reduced the M1/M2 macrophage ratio, promoting fibrosis.
Authors
- Jiǎtāo Xiè (ORCID: https://orcid.org/0000-0003-1961-0338)
- Qian Sun (ORCID: https://orcid.org/0000-0002-8038-0706)
- Qiao Tang (ORCID: https://orcid.org/0000-0001-7193-698X)
- Yifei Wang (ORCID: https://orcid.org/0000-0003-2813-1128)
- Chong Dong (ORCID: https://orcid.org/0000-0003-4287-303X)
Institutions
- Tianjin University (CN)
- Tianjin First Center Hospital (CN)
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-02-05
- DOI
- https://doi.org/10.3389/fimmu.2025.1510500
- Citations
- 7
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 5.64