Outer retina micro-inflammation is driven by T cell responses prior to retinal degeneration in early age-related macular degeneration
Our data support that activation and accumulation of memory T cells can be considered as a hallmark of early AMD, and that adaptive immunosenescence likely to contribute to the chronic inflammation associated with RPE damage and the progression to large lesions as seen in GA.
Authors
- S. Clark
- Theda Ulrike Patricia Bartolomaeus (ORCID: https://orcid.org/0000-0002-5156-7184)
- Nicola Wilck (ORCID: https://orcid.org/0000-0003-3189-5364)
- Lucas Stürzbecher
- Olaf Strauß (ORCID: https://orcid.org/0000-0002-6272-8596)
- Marius Ueffing (ORCID: https://orcid.org/0000-0003-2209-2113)
- Andjela Sekulic
- Nadine Reichhart
- Sergio Crespo‐Garcia (ORCID: https://orcid.org/0000-0002-8640-9135)
- Hendrik Bartolomaeus (ORCID: https://orcid.org/0000-0003-4288-3828)
- Sylvia Bolz
Institutions
- Max Delbrück Center (DE)
- University Medical Center Freiburg (DE)
- University of Manchester (GB)
- Humboldt-Universität zu Berlin (DE)
- Universitätsklinikum Würzburg (DE)
- German Centre for Cardiovascular Research (DE)
- STZ eyetrial (DE)
- Université de Montréal (CA)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
- University of Tübingen (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-02-05
- DOI
- https://doi.org/10.3389/fimmu.2025.1520188
- Citations
- 2
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.41