Stachydrine targeting tumor-associated macrophages inhibit colorectal cancer liver metastasis by regulating the JAK2/STAT3 pathway
The findings of this study demonstrate that STA exerts an inhibitory effect on colorectal cancer liver metastasis by targeting macrophages and impeding their M2 polarization via the JAK2/STAT3 pathway. Furthermore, the combination of STA with anti-PD-1 therapy has been observed to enhance the effectiveness of immune checkpoint blockade and reduce tumor spread, indicating the potential of STA to improve the efficacy of immunotherapy for liver metastases.
Authors
- Shuangjiao Deng
- Gang Xue (ORCID: https://orcid.org/0000-0002-2733-5770)
- Fei Gao (ORCID: https://orcid.org/0000-0001-9741-9390)
- Yuyi Yuan
- Yu‐Shi Tian (ORCID: https://orcid.org/0000-0002-8988-9453)
- Zhiqiang Zhao (ORCID: https://orcid.org/0000-0003-2556-1018)
- Heng Fan (ORCID: https://orcid.org/0000-0002-1100-0757)
- Chunhua Yang (ORCID: https://orcid.org/0000-0003-2550-1509)
- Jingbo Wang (ORCID: https://orcid.org/0009-0009-8366-979X)
Institutions
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-02-05
- DOI
- https://doi.org/10.3389/fphar.2025.1514158
- Citations
- 8
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 6.38