Symptomatic neurosyphilis in HIV-negative patients: a retrospective cohort study

An elevated CSF protein level and the parenchymal type were associated with poor outcome. This study revealed that clinical manifestations of neurosyphilis vary, and that the majority of patients had elevated CSF cell and protein levels and a normal intracranial pressure. The PLR was higher and the LMR was lower in the parenchymal type than in the interstitial type. Only a small proportion of patients had favorable outcomes. CSF protein level and parenchymal type may be risk factors for poor prognosis.