Ectopic expression of the cation-chloride cotransporter KCC2 in blood exosomes as a biomarker for functional rehabilitation
We successfully validated our previous findings, supporting the potential therapeutic benefits of bumetanide in mitigating post-traumatic depression (PTD) following TBI. This effect was correlated with the recovery of KCC2 expression in the blood exosomes, the prevention of extensive neuronal loss among the interneurons, and changes in secondary neurogenesis.
Authors
- Amandine Consumi
- Christophe Pellegrino (ORCID: https://orcid.org/0000-0002-0669-4918)
- Ashok Srinivasan (ORCID: https://orcid.org/0000-0001-9058-537X)
- M. Tessier (ORCID: https://orcid.org/0000-0001-8753-829X)
- Jérôme Laurin (ORCID: https://orcid.org/0000-0001-9692-0060)
- Claudio Rivera (ORCID: https://orcid.org/0000-0003-2462-6561)
- Laura Prato (ORCID: https://orcid.org/0000-0001-7767-4554)
- A. Rezzag Lebza
Institutions
- JSS Academy of Higher Education and Research (IN)
- University of Helsinki (FI)
- Inserm (FR)
- Aix-Marseille Université (FR)
Publication Details
- Journal
- Frontiers in Molecular Neuroscience
- Published
- 2025-02-05
- DOI
- https://doi.org/10.3389/fnmol.2025.1522571
- Citations
- 2
- Primary Topic
- Ion channel regulation and function
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Fondation des Gueules Cassées