Glutamate dehydrogenase 1-dependent α-ketoglutarate promotes hepatitis B virus transcription by modulating histone methylations on the covalently closed circular DNA minichromosome
Our findings highlight the importance of glutamine metabolism in HBV transcription and suggest that glutamine deprivation is a potential strategy for silencing cccDNA transcription.
Authors
- Min-Li Yang
- Sheng‐Tao Cheng
- Haibo Yu (ORCID: https://orcid.org/0009-0003-0136-4762)
- Haijun Deng (ORCID: https://orcid.org/0000-0002-4890-192X)
- Zhihong Li (ORCID: https://orcid.org/0000-0003-0655-0567)
- Zhen-Zhen Zhang
- Dapeng Zhang (ORCID: https://orcid.org/0000-0002-0206-7490)
- Juan Chen (ORCID: https://orcid.org/0000-0001-6920-7972)
- Hui Zhang (ORCID: https://orcid.org/0000-0003-0129-0305)
- Xin He (ORCID: https://orcid.org/0000-0001-8686-3971)
- Weixian Chen (ORCID: https://orcid.org/0009-0003-0595-0523)
- Ming Tan (ORCID: https://orcid.org/0000-0001-7547-4145)
- Ji‐Hua Ren
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Clinical and Molecular Hepatology
- Published
- 2025-02-05
- DOI
- https://doi.org/10.3350/cmh.2024.0694
- Citations
- 6
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 4.84