PyBootNet: a python package for bootstrapping and network construction

We show that PyBootNet generates robust bootstrapped network metrics and identifies significant differences in one or more network metrics between pairs of networks. Our analysis of the previously published PCOS gut microbiome data also showed that our network analysis uncovered patterns and treatment effects missed in the original study. PyBootNet provides a powerful and extendible Python bioinformatics solution for bootstrapping analysis and network construction that can be applied to microbes, genes, metabolites and other biological data appropriate for network correlation comparison and analysis.