Unraveling the association and regulatory role of miR-146b-5p in coronary artery disease
Our study revealed that miR-146b-5p was higher in the PBMCs of CAD patients than non-CAD individuals, and established a correlation between miR-146b-5p and occurrence and severity of CAD. In addition, the inflammatory role of miR-146b-5p is mediated by targeting IKKβ.
Authors
- Xiaozhu Ma
- Jiangtao Yan (ORCID: https://orcid.org/0000-0002-0979-4885)
- Yi He (ORCID: https://orcid.org/0000-0002-4055-621X)
- Qiushi Luo (ORCID: https://orcid.org/0009-0007-8965-8210)
- Ying Wen (ORCID: https://orcid.org/0000-0003-0867-3958)
- Li Zhou (ORCID: https://orcid.org/0000-0002-0555-4390)
- Qidamugai Wuyun
- Shuai Mei
- Ziyang Cai
Institutions
- Laboratory of Molecular Genetics (PL)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- BMC Cardiovascular Disorders
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1186/s12872-025-04530-0
- Citations
- 2
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China