PTEN suppresses renal cell carcinoma proliferation and migration via inhibition of the PI3K/AKT pathway
Our findings demonstrate that PTEN overexpression in RCC cells leads to decreased PI3K/AKT signaling, decreasing cell viability and migration. This study highlights the critical role of PTEN in RCC progression and suggests potential therapeutic targets for intervention.
Authors
- Wen Luo (ORCID: https://orcid.org/0000-0002-0621-2886)
- Ya‐ling Tang (ORCID: https://orcid.org/0000-0002-2010-3571)
- Dongmei Jiang (ORCID: https://orcid.org/0000-0002-7926-8645)
- Xu Xu
- Xiaohong Liang
- Jie Chen (ORCID: https://orcid.org/0000-0002-2470-9159)
Institutions
- Second Military Medical University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Changhai Hospital (CN)
Publication Details
- Journal
- World Journal of Surgical Oncology
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1186/s12957-025-03658-9
- Citations
- 5
- Primary Topic
- PI3K/AKT/mTOR signaling in cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- National Natural Science Foundation of China