Therapeutic effect of dihydroartemisinin on Alzheimer’s disease model mice with senile macular degeneration
DHA combined with BCL2 and ATG protein, through promoting autophagy protein, can reduce the damage of cerebral cortex structure in AD mice, reduce the deposition of extracellular β-amyloid protein, and then improve the memory ability of AD model mice. DHA treatment is superior to donepezil monotherapy.
Authors
- Gong Xuewu
- Han Gao (ORCID: https://orcid.org/0000-0002-2457-8152)
- Wang Yuejing
- Yao Hongbo
- Yuchun Wang (ORCID: https://orcid.org/0000-0002-8362-5131)
- Zhang Meng
- Zhang Keshuang
Institutions
- Qiqihar Medical University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1186/s40001-025-02315-x
- Citations
- 3
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- Natural Science Foundation of Heilongjiang Province