Structurally Diverse New Metabolites from Three Hadal Trench-Derived Microorganisms
Two new tetraene lactone derivatives (<b>1</b> and <b>2</b>), two new α-pyrone derivatives (<b>3</b> and <b>4</b>), three compounds reported as natural products for the first time [an α-pyrone derivative (<b>5</b>), an indole-diketopiperazine alkaloid (<b>6</b>), and a β-amino acid derivative (<b>8</b>)], and 11 known compounds (<b>7</b>, <b>9</b>-<b>18</b>), were obtained from microorganisms isolated from hadal trench sediments in the Pacific Ocean. Their structures were determined using NMR, HRESIMS, optical rotatory dispersion (ORD) spectra, NMR calculations followed by DP4+ analysis, electronic circular dichroism (ECD) calculations, X-ray crystallography analysis, and advanced Marfey's and modified Mosher eater methods. Microbial broth dilution assay suggested that compounds <b>6</b>-<b>11</b> and <b>15</b> had weak antibacterial effects.
Authors
- Weiqing Ruan
- Wenjia Huang (ORCID: https://orcid.org/0000-0003-4621-7101)
- Dehua Yang (ORCID: https://orcid.org/0000-0003-3028-3243)
- Qun Li (ORCID: https://orcid.org/0000-0002-5501-8262)
- Junfeng Wang (ORCID: https://orcid.org/0000-0001-8914-5174)
- Hui‐Zi Jin (ORCID: https://orcid.org/0000-0002-6901-5898)
- Ming‐Wei Wang (ORCID: https://orcid.org/0000-0001-6550-9017)
- Xiǎo Zhang (ORCID: https://orcid.org/0000-0003-0078-9075)
- Yunan Liu (ORCID: https://orcid.org/0000-0001-5461-6570)
- Li Ding (ORCID: https://orcid.org/0000-0001-7191-908X)
- Qingyun Peng (ORCID: https://orcid.org/0000-0002-8388-5718)
- Xiaoyan Pang (ORCID: https://orcid.org/0009-0001-1972-0265)
Institutions
- Shanghai Jiao Tong University (CN)
- Chinese Academy of Sciences (CN)
- Fudan University (CN)
- Institute of Oceanology (CN)
- South China Sea Institute Of Oceanology (CN)
- National Center for Drug Screening (CN)
- Institute of Deep-Sea Science and Engineering (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- ACS Omega
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1021/acsomega.4c11083
- Citations
- 2
- Primary Topic
- Hydrocarbon exploration and reservoir analysis
- Type
- article
- Field-Weighted Citation Impact
- 1.73
Funders
- Major Science and Technology Project of Hainan Province