Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma (MEITL) Causing Small Intestinal Perforation Associated With Adnexal Metastasis: A Case Report

Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a rare and aggressive form of peripheral T-cell lymphoma originating from intestinal epithelial lymphocytes and is associated with a poor prognosis. We present the case of a 50-year-old woman who developed a gastrointestinal perforation, initially suspected to be due to ovarian cancer with peritoneal dissemination. The patient underwent laparoscopic adnexal resection and laparotomy for the intestinal perforation. Postoperative pathology confirmed that the cause of the intestinal perforation and enlarged adnexa was MEITL. Prompt chemotherapy was administered, followed by autologous hematopoietic stem cell transplantation. Despite rapid disease progression, effective management led to favorable treatment outcomes. Early diagnosis and timely intervention are crucial to improve the prognosis of patients with MEITL.

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Journal
Cureus
Published
2025-02-05
DOI
https://doi.org/10.7759/cureus.78534
Primary Topic
Lymphoma Diagnosis and Treatment
Type
article
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article

Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma (MEITL) Causing Small Intestinal Perforation Associated With Adnexal Metastasis: A Case Report

Masatomo Kuno, Hironori Uruga, Yutaka Hanaoka, Kazuya Okamoto et al.
Cureus
Lymphoma Diagnosis and Treatment
article

Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma (MEITL) Causing Small Intestinal Perforation Associated With Adnexal Metastasis: A Case Report

Masatomo Kuno, Hironori Uruga, Yutaka Hanaoka, Kazuya Okamoto, Daisuke Kaji
article en

Abstract

Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a rare and aggressive form of peripheral T-cell lymphoma originating from intestinal epithelial lymphocytes and is associated with a poor prognosis. We present the case of a 50-year-old woman who developed a gastrointestinal perforation, initially suspected to be due to ovarian cancer with peritoneal dissemination. The patient underwent laparoscopic adnexal resection and laparotomy for the intestinal perforation. Postoperative pathology confirmed that the cause of the intestinal perforation and enlarged adnexa was MEITL. Prompt chemotherapy was administered, followed by autologous hematopoietic stem cell transplantation. Despite rapid disease progression, effective management led to favorable treatment outcomes. Early diagnosis and timely intervention are crucial to improve the prognosis of patients with MEITL.

CureusVol. 17(2)
Okinaka Memorial Adult Disease Research Institute (JP), Toranomon Hospital (JP)
Zero hunger
Openalex Percentile: Top 97%
Lymphoma Diagnosis and Treatment
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Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma (MEITL) Causing Small Intestinal Perforation Associated With Adnexal Metastasis: A Case Report — Masatomo Kuno, Hironori Uruga, et al. · Cureus (2025) | TGRS Research Map | TGRS