Low-activity [18F]-somatostatin receptor (SSTR) imaging using [18F]SiTATE on a long axial field-of-view PET/CT scanner
Reducing the administered activity of injected [<sup>18</sup>F]SiTATE by 66% to 1 MBq/kg (HS & UHS) is feasible in a LAFOV PET/CT scanner, maintaining clinically diagnostic image quality without statistically significant deviations in PET uptake parameters and MTV. Furthermore, in low activity [<sup>18</sup>F]SiTATE PET/CT, the UHS mode improves image quality and noise as well as lesion detectability compared to HS mode, further reinforcing the clinical benefits of this recently introduced reconstruction mode.
Authors
- Gerald Reischl (ORCID: https://orcid.org/0000-0003-3961-116X)
- Helmut Dittmann (ORCID: https://orcid.org/0000-0001-6840-5571)
- Thorben Groß (ORCID: https://orcid.org/0000-0002-7907-4373)
- Andreas Brendlin (ORCID: https://orcid.org/0000-0002-5961-9727)
- Lena S. Kiefer (ORCID: https://orcid.org/0000-0002-3999-559X)
- Christian la Fougère (ORCID: https://orcid.org/0000-0001-7519-0417)
- Eduardo Calderón (ORCID: https://orcid.org/0009-0000-3837-7151)
- Nils Florian Trautwein (ORCID: https://orcid.org/0000-0003-3397-6299)
- Pia M. Linder (ORCID: https://orcid.org/0000-0002-0615-4137)
- Martina Hinterleitner (ORCID: https://orcid.org/0000-0001-7137-0541)
- Fabian Schmidt (ORCID: https://orcid.org/0000-0003-1886-4803)
- Wenhong Lan (ORCID: https://orcid.org/0000-0001-5453-6351)
- Philippe Driessen
Institutions
- Siemens (Germany) (DE)
- German Cancer Research Center (DE)
- European Neuroendocrine Tumor Society (DE)
- University of Tübingen (DE)
Publication Details
- Journal
- EJNMMI Physics
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1186/s40658-025-00720-z
- Citations
- 4
- Primary Topic
- Neuroendocrine Tumor Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- Deutsche Forschungsgemeinschaft
- Siemens Healthineers