Comparative Antioxidant Activity of The Synthesized (E)-Chalcones

Depletion of dietary antioxidants has been related to rising of oxidative stress that causes chronic and degenerative diseases such as cancers, Alzheimer and aging. Therefore, finding of a readily available antioxidant is essential to offer potential chemotherapeutics. In this study, (E)-1,3-diphenylprop-2-en-1-one (1), (E)-1-(3-nitrophenyl)-3-phenylprop-2-en-1-one (2), (E)-3-(furan-2-yl)-1-(3-nitropheyl)prop-2-en-1-one (3), (E)-1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one (4), (E)-3-(furan-2-yl)-1-(2-hydroxyphenyl)prop-2-en-1-one (5), (E)-1-(2-hydroxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one (6) and (E)-3-(4-(dimethylamino)phenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one (7), that readily obtained through the Crossed-Aldol condensation between arylmethyl ketones and aromatic aldehydes, were evaluated for the antioxidant activity by using the 2,2-Diphenyl-1-picrylhydrazyl (DPPH), 2,2′-Azinobis-(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) and Nitric oxide (NO) assays. Among the chalcones investigated, compound 7 has displayed antioxidant activity in the ABTS assay with IC50 value of 464 μM (calcd. 124 µg/mL) indicating a para-dimethylamino substitution in the B ring of chalcone enhances reduction of cationic free radical ABTS•+.