Marfan syndrome and multiple myeloma: A coincidence or tendency?

Marfan Syndrome (MFS) is an autosomal dominant connective tissue disorder characterized by musculoskeletal, ocular, and cardiovascular abnormalities. It results from a mutation in the fibrillin-1 gene, leading to its deficiency and often causing overactivation of the TGF-β signaling pathway, which may contribute to cancer development.