Sericin’s Potential in Osteoporosis Management: The Roles of L-Serine and D-Serine in Bone Metabolism Regulation
This study demonstrates that sericin modulates bone metabolism by enhancing osteoblast activity through L-serine and inhibiting osteoclastogenesis via D-serine. Sericin supplementation improved trabecular bone mass in an osteoporosis model, highlighting its potential for bone health.
Authors
- Xiangguo Che (ORCID: https://orcid.org/0000-0002-7272-1806)
- HaeYong Kweon (ORCID: https://orcid.org/0000-0001-8761-4897)
- Suk Keun Lee (ORCID: https://orcid.org/0000-0001-6255-4197)
- Jong Ho Choi (ORCID: https://orcid.org/0000-0003-2632-8242)
- Shihyun Kim (ORCID: https://orcid.org/0000-0002-2091-3195)
- Ji Hae Lee (ORCID: https://orcid.org/0000-0002-2314-5654)
- Jwa-Young Kim (ORCID: https://orcid.org/0000-0002-8140-3121)
- Seong‐Gon Kim (ORCID: https://orcid.org/0000-0001-5088-2732)
- Je‐Yong Choi (ORCID: https://orcid.org/0000-0002-5057-8842)
- Joon Ha Lee
Institutions
- Gangneung–Wonju National University (KR)
- Rural Development Administration (KR)
- Kyungpook National University (KR)
- Hallym University Kangnam Sacred Heart Hospital (KR)
- Hallym University Medical Center (KR)
Publication Details
- Journal
- Nutrients
- Published
- 2025-02-04
- DOI
- https://doi.org/10.3390/nu17030574
- Citations
- 4
- Primary Topic
- Silk-based biomaterials and applications
- Type
- article
- Field-Weighted Citation Impact
- 2.39