A Comparative Study of Dietary Intake, Nutritional Status, and Frailty in Outpatients and Inpatients with Liver Cirrhosis

<b>Background:</b> Liver cirrhosis is associated with significant nutritional challenges, including malnutrition, sarcopenia, and frailty, which impact clinical outcomes. The severity of these issues may vary between inpatient and outpatient settings, but there is a limited understanding of how these conditions manifest in these populations. This study aims to compare the nutritional status, dietary intake, and frailty in outpatients and inpatients with liver cirrhosis and to explore potential sex-specific differences. <b>Methods:</b> This prospective observational study enrolled 195 patients with liver cirrhosis from the Gastroenterology ward and Outpatient Clinic of Policlinico Umberto I, Sapienza University of Rome, between May 2023 and July 2024. Nutritional status was assessed using anthropometric measurements, dietary recall, and food frequency questionnaires. Sarcopenia was evaluated using the SARC-F questionnaire and handgrip strength. Frailty was assessed using the Liver Frailty Index (LFI). Data on clinical characteristics, comorbidities, and disease severity were also recorded. <b>Results:</b> The inpatient group (<i>n</i> = 69) had significantly lower BMI, mid-upper arm circumference, and triceps skinfold compared to outpatients (<i>n</i> = 126). Inpatients exhibited higher frailty, with 73.9% classified as frail according to the LFI, compared to 39.6% in outpatients (<i>p</i> < 0.001). Dietary intake revealed that 91% of inpatients had an energy intake deficit compared to 76% of outpatients (<i>p</i> = 0.009). Protein intake was inadequate in 84% of inpatients versus 61% of outpatients (<i>p</i> < 0.001). Sex-specific analysis showed that females had a higher prevalence of sarcopenia than males (64.4% vs. 38.2%, <i>p</i> < 0.001) and experienced more significant protein deficits (74.3% vs. 57.6%, <i>p</i> = 0.021). Females also had higher LFI score (4.77 ± 0.88 vs. 4.45 ± 0.91, <i>p</i> = 0.034). Multivariate analysis showed that CTP, LFI, and protein deficit are independently associated with hospitalization. <b>Conclusions:</b> Inpatients with liver cirrhosis are at higher risk for malnutrition, frailty, and inadequate nutrient intake compared to outpatients, emphasizing the need for targeted nutritional interventions in hospital settings. Additionally, females with cirrhosis are more prone to sarcopenia and frailty, requiring gender-specific approaches to nutrition.