Multifaceted Biomarkers Suggest a Similar Profile of <scp>CNS</scp> Pathology in Relapsing and Progressive <scp>MS</scp>
Serum and CSF soluble biomarker profiles and post-mortem pathology do not differentiate RRMS from PPMS diagnoses but reflect the extent of inflammation and tissue damage. Detailed assessment of MS-associated inflammation and tissue damage may enhance classification and therapeutic strategies.
Authors
- Beatrijs Wokke (ORCID: https://orcid.org/0000-0002-2616-8464)
- Inge Huitinga
- Katelijn M. Blok (ORCID: https://orcid.org/0000-0001-9530-5023)
- Ari Green (ORCID: https://orcid.org/0000-0001-9275-3066)
- Lucia Giannini (ORCID: https://orcid.org/0000-0002-3132-1750)
- Kirtana Ananth
- Romy A. M. Klein Kranenbarg (ORCID: https://orcid.org/0009-0007-3460-9948)
- Ahmed Abdelhak (ORCID: https://orcid.org/0000-0001-9731-4169)
- Harro Seelaar (ORCID: https://orcid.org/0000-0003-1989-7527)
- Joost Smolders (ORCID: https://orcid.org/0000-0001-9766-8661)
- Hendrik J. Engelenburg (ORCID: https://orcid.org/0000-0002-3766-3241)
- Aletta M.R. van den Bosch (ORCID: https://orcid.org/0000-0001-8886-8928)
- Janet de Beukelaar
Institutions
- Netherlands Institute for Neuroscience (NL)
- University of California, San Francisco (US)
- Erasmus MC (NL)
- Albert Schweitzer Ziekenhuis (NL)
Publication Details
- Journal
- European Journal of Neurology
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1111/ene.70052
- Citations
- 5
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 7.36
Funders
- Stichting MS Research