Real-time multimodal imaging of daptomycin action on the cell wall of adherent Staphylococcus aureus
Daptomycin, at clinically relevant concentrations, rapidly eradicated adherent bacteria in the exponential growth phase, demonstrating an efficiency comparable to its action against planktonic cells. Prolonged exposure to the antibiotic caused marked alterations in the bacterial cell wall, including surface roughening and perforation, as revealed by multimodal imaging. However, daptomycin effectiveness diminished as biofilm formation progressed, underscoring the need for further exploration of optimized clinical strategies.
Authors
- Romain Briandet (ORCID: https://orcid.org/0000-0002-8123-3492)
- Marie‐Pierre Fontaine‐Aupart
- Julien Deschamps (ORCID: https://orcid.org/0000-0002-6119-2419)
- Rym Boudjemaa
- C. Marlière (ORCID: https://orcid.org/0000-0001-7769-8900)
- Alexis Canette (ORCID: https://orcid.org/0000-0002-2750-6568)
- Karine Steenkeste (ORCID: https://orcid.org/0000-0002-2890-6328)
Institutions
- Centre National de la Recherche Scientifique (FR)
- AgroParisTech (FR)
- Université Paris-Saclay (FR)
- Microbiologie de l’alimentation au service de la santé (FR)
- Sorbonne Université (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Institut de Biologie Paris-Seine (FR)
- Institut des Sciences Moléculaires d'Orsay (FR)
Publication Details
- Journal
- BMC Research Notes
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1186/s13104-025-07130-5
- Citations
- 2
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- Agence Nationale de la Recherche