The Alzheimer's Association Global Biomarker Standardization Consortium (GBSC) plasma phospho‐tau Round Robin study
Paired plasma and cerebrospinal fluid (CSF) samples from twenty-five Alzheimer's disease (AD) and 15 non-AD patients were measured blind. Thirty-three plasma assays were compared, for phosphorylated tau-181 (p-tau181), 205, 212, 217 and 231. Plasma p-tau217 consistently had the highest fold-change and was best correlated between assays. Plasma-CSF correlations were weak to moderate. There was lack of commutability for four candidate reference materials.
Authors
- Johan Gobom (ORCID: https://orcid.org/0000-0001-6193-6193)
- Shweta Iyengar
- Alex Forrest‐Hay
- Nicholas James Ashton (ORCID: https://orcid.org/0000-0002-3579-8804)
- Manu Vandijck
- Divya Bali (ORCID: https://orcid.org/0000-0003-3178-1586)
- Mathias Droescher (ORCID: https://orcid.org/0000-0003-0857-1425)
- Jacob N. Wohlstadter (ORCID: https://orcid.org/0009-0000-4467-6895)
- Robert A. Rissman (ORCID: https://orcid.org/0000-0001-9245-8278)
- Stefan Barghorn
- Kaj Blennow (ORCID: https://orcid.org/0000-0002-1890-4193)
- María C. Carrillo (ORCID: https://orcid.org/0000-0003-3057-2387)
- Wagner S. Brum (ORCID: https://orcid.org/0000-0002-9777-0559)
- Daniel Romero (ORCID: https://orcid.org/0000-0003-1505-3247)
- Erik Stoops (ORCID: https://orcid.org/0000-0001-9989-4486)
- Fernando González‐Ortiz (ORCID: https://orcid.org/0000-0001-7897-9456)
- Kishore S. Malyavantham (ORCID: https://orcid.org/0000-0002-0970-8684)
- Shieh‐Yueh Yang (ORCID: https://orcid.org/0000-0002-7850-4597)
- Jeroen Vanbrabant
- Ashvini Keshavan (ORCID: https://orcid.org/0000-0003-1043-5721)
- Catherine Demos (ORCID: https://orcid.org/0000-0003-3914-1954)
- Jonathan M. Schott (ORCID: https://orcid.org/0000-0003-2059-024X)
- Przemysław Radosław Kac (ORCID: https://orcid.org/0000-0001-5083-0924)
- Alexander Jethwa (ORCID: https://orcid.org/0000-0003-3869-8662)
- Oskar Hansson (ORCID: https://orcid.org/0000-0001-8467-7286)
- Nathalie Le Bastard (ORCID: https://orcid.org/0000-0002-7981-2866)
- Charlotte Lambrechts (ORCID: https://orcid.org/0009-0007-6720-0727)
- Ulf Andréasson (ORCID: https://orcid.org/0000-0001-8622-052X)
- Laia Montoliu‐Gaya (ORCID: https://orcid.org/0000-0001-7684-6318)
- Gallen Triana‐Baltzer (ORCID: https://orcid.org/0000-0003-0612-1236)
- Andreas Jeromin
- Hartmuth C. Kolb (ORCID: https://orcid.org/0000-0003-2414-5792)
- Bingqing Zhang (ORCID: https://orcid.org/0000-0003-0739-0956)
- George B. Sigal (ORCID: https://orcid.org/0000-0001-7149-6400)
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Yuling Luo
- Leslie M. Shaw (ORCID: https://orcid.org/0000-0002-7650-1210)
- Burak Arslan (ORCID: https://orcid.org/0000-0001-6629-5153)
- Laura Stoeckl
- Shorena Janelidze
- Xiaomei Xu
- HaYeun Ji
- Meenakshi Khare
- Maxime Van Loo
Institutions
- University of Southern California (US)
- Ablynx (Belgium) (BE)
- University of Science and Technology of China (CN)
- Alzheimer's Association (US)
- Autism Research Institute (US)
- Universidade Federal do Rio Grande do Sul (BR)
- University of Wisconsin–Madison (US)
- King's College London (GB)
- Lund University (SE)
- South London and Maudsley NHS Foundation Trust (GB)
- Stavanger University Hospital (NO)
- Hong Kong Science and Technology Parks Corporation (HK)
- Sahlgrenska University Hospital (SE)
- Centre for Mental Health (GB)
- Sorbonne Université (FR)
- Roche Pharma AG (Germany) (DE)
- Quanterix (United States) (US)
- Pitié-Salpêtrière Hospital (FR)
- UK Dementia Research Institute (GB)
- AbbVie (Germany) (DE)
- Skåne University Hospital (SE)
- Janssen (United States) (US)
- National Hospital for Neurology and Neurosurgery (GB)
- Institut du Cerveau (FR)
- Meso Scale Discovery (United States) (US)
- ADx NeuroSciences
- University College London (GB)
- Fujirebio (Belgium) (BE)
- University of Pennsylvania (US)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/alz.14508
- Citations
- 42
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 60.32
Funders
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Eli Lilly and Company
- Familjen Erling-Perssons Stiftelse
- Cure Alzheimer's Fund
- Stiftelsen för Gamla Tjänarinnor
- EU Joint Programme – Neurodegenerative Disease Research
- Australian Government
- GHR Foundation
- National Institute for Health and Care Research
- University College London
- European Commission
- Lunds Universitet
- Eisai
- Hjärnfonden
- Knut och Alice Wallenbergs Stiftelse
- Vetenskapsrådet
- Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse
- Skånes universitetssjukhus
- UK Dementia Research Institute
- National Institutes of Health
- Parkinsonfonden
- HORIZON EUROPE Framework Programme
- European Research Council
- National Institute on Aging