Serum Carnosinase 1 Is Not Associated with Insulin Resistance or Glucose Metabolism in a Type 1 Diabetes Cohort

<b>Background/Objectives</b>: Preclinical studies suggest that the deleterious effect of a high serum carnosinase 1 (CN1) concentration is attributed to its adverse effects on insulin sensitivity and glucose metabolism. However, there is little evidence for a modulating role of CN1 in glucose metabolism in humans. <b>Methods</b>: We measured serum CN1 concentration in an observational type 1 diabetes cohort of 172 patients in whom glucose variability (MAGE, MODD, SD of individual blood glucose, mean, and CV) was recorded by blinded continuous glucose monitoring for 5-7 days. Furthermore, insulin dose per kg body weight was compared. <b>Results</b>: Insulin sensitivity (insulin dosage) and glucose variability parameters did not differ between different CN1 tertiles (<i>p</i> > 0.05). <b>Conclusions</b>: There was no association of serum CN1 with indices of glucose variability in this type 1 diabetes cohort.