Long‐Term Outcomes on Pallidal Neurostimulation for Dystonia: A Controlled, Prospective 10‐Year Follow‐Up
This study presents the longest prospective, multicenter follow-up of pallidal neurostimulation in generalized and segmental dystonia. Two-thirds of patients showed strong and stable long-term improvements of dystonia, confirming sustained efficacy and safety over 10 years in treatment-refractory dystonic patients. However, one-third experienced primary (3/40) or secondary (10/40) treatment failure. Diagnostic advances, including genetic testing, and technological progress in pallidal neurostimulation may help to reduce the non-responder rates in the future. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Authors
- Jan‐Uwe Müller (ORCID: https://orcid.org/0000-0002-9342-5942)
- Andrea A. Kühn (ORCID: https://orcid.org/0000-0002-4134-9060)
- Alfons Schnitzler (ORCID: https://orcid.org/0000-0002-6414-7939)
- Jan Vesper
- R. Erasmi
- Inger Marie Skogseid (ORCID: https://orcid.org/0000-0001-7811-927X)
- Jens Volkmann (ORCID: https://orcid.org/0000-0002-9570-593X)
- Wilhelm Eisner
- Nils Warneke
- Patricia Krause (ORCID: https://orcid.org/0000-0001-9063-0556)
- Tobias Warnecke (ORCID: https://orcid.org/0000-0003-4423-6114)
- Gerd‐Helge Schneider (ORCID: https://orcid.org/0000-0002-1301-2938)
- Thomas Prokop (ORCID: https://orcid.org/0000-0002-2629-4110)
- Frank Steigerwald (ORCID: https://orcid.org/0000-0002-8305-1684)
- Günther Deuschl (ORCID: https://orcid.org/0000-0002-4176-9196)
- Philipp Mahlknecht (ORCID: https://orcid.org/0000-0003-0671-0516)
- Jörg Müller
- Werner Poewe
Institutions
- Oslo University Hospital (NO)
- Innsbruck Medical University (AT)
- University of Freiburg (DE)
- University of Münster (DE)
- University of Würzburg (DE)
- Universitätsmedizin Greifswald (DE)
- Christian-Albrechts-Universität zu Kiel (DE)
- Vivantes Klinikum (DE)
- Klinikum Osnabrück (DE)
- Heinrich Heine University Düsseldorf (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Movement Disorders
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1002/mds.30130
- Citations
- 5
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.95
Funders
- Deutsche Forschungsgemeinschaft