Motor Symptom Variability in Parkinson's Disease: Implications for Personalized Trial Outcomes?
These findings suggest that day-to-day symptom variability impacts MDS-UPDRS scores in smaller and shorter-duration trials of symptomatic interventions. Continuous monitoring using wearable sensors may offer more accurate and reliable measures for evaluating PD motor symptoms in clinical studies. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Authors
- Jules M. Janssen Daalen (ORCID: https://orcid.org/0000-0001-6290-5882)
- Bart Post (ORCID: https://orcid.org/0000-0002-7271-864X)
- Maudy van der Heiden
- Marjan J. Meinders (ORCID: https://orcid.org/0000-0001-6491-7035)
Institutions
- Radboud University Nijmegen (NL)
- Radboud University Medical Center (NL)
Publication Details
- Journal
- Movement Disorders
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1002/mds.30133
- Citations
- 8
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 11.11
Funders
- Michael J. Fox Foundation for Parkinson's Research