Nitidine chloride inhibits the progression of hepatocellular carcinoma by suppressing IGF2BP3 and modulates metabolic pathways in an m6A-dependent manner
Our study suggest that NC may exert its anti-HCC effects by downregulating IGF2BP3, inhibiting the m<sup>6</sup>A modification levels of metabolic-related genes, thereby reducing their stability and expression. Such insights provide a new direction in the study of NC's anti-HCC mechanisms and offer novel perspectives for the treatment of HCC patients, focusing on both metabolic levels and m<sup>6</sup>A modification levels.
Authors
- Rong‐Quan He (ORCID: https://orcid.org/0000-0002-7752-2080)
- Yi‐Wu Dang (ORCID: https://orcid.org/0000-0002-7793-1239)
- Jinmei Li
- Gang Chen (ORCID: https://orcid.org/0000-0003-2402-2987)
- Zhi‐Guang Huang (ORCID: https://orcid.org/0000-0003-4457-9491)
- Yulin Deng (ORCID: https://orcid.org/0000-0002-0720-4052)
- Zhen-dong Chen
- Dandan Xiong (ORCID: https://orcid.org/0000-0002-5362-0938)
- S.-J. An (ORCID: https://orcid.org/0009-0007-3935-0322)
Institutions
- Guangxi Medical University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1186/s10020-025-01095-8
- Citations
- 8
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 6.45
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangxi Province
- Guangxi Medical University
- Division of Graduate Education