Thermoresponsive PNIPAM/FeRh Smart Composite Activated by a Magnetic Field for Doxorubicin Release
The ability to control the physical properties of the thermoresponsive polymer PNIPAM by the magnetocaloric effect was demonstrated by in situ experiments on the PNIPAM/FeRh smart composite. The concept of drug release from a smart composite under the application of a 3 T magnetic field was demonstrated using doxorubicin as a model drug. The resulting release of the drug under the application of a magnetic field was detected by using a combination of UV–vis and Raman spectroscopy. In vitro studies have demonstrated a high degree of PNIPAM/FeRh scaffold biocompatibility for the primary mouse embryonic fibroblast (PMEF) cell culture. PMEFs effectively adhered to the PNIPAM/FeRh scaffold surface and showed high metabolic and proliferative activity for 72 h after seeding.
Authors
- E. K. Murliev (ORCID: https://orcid.org/0009-0009-7742-8527)
- Anton L. Popov (ORCID: https://orcid.org/0000-0003-2643-4846)
- Elizaveta S. Permyakova (ORCID: https://orcid.org/0000-0003-2581-0803)
- К. Ш. Рабаданов (ORCID: https://orcid.org/0000-0001-8876-415X)
- I. М. Chirkova (ORCID: https://orcid.org/0000-0001-5455-4197)
- A. M. Aliev (ORCID: https://orcid.org/0000-0002-7765-5692)
- Abdulkarim A. Amirov (ORCID: https://orcid.org/0000-0001-5311-2063)
- I. V. Savintseva
- D. M. Yusupov
Institutions
- Russian Academy of Sciences (RU)
- Hochschule Bielefeld (DE)
- National University of Science and Technology (ZW)
- Institute of Theoretical and Experimental Biophysics (RU)
- Institute of Physics. HI Amirkhanova (RU)
Publication Details
- Journal
- ACS Applied Engineering Materials
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1021/acsaenm.4c00730
- Citations
- 7
- Primary Topic
- Hydrogels: synthesis, properties, applications
- Type
- article
- Field-Weighted Citation Impact
- 4.14
Funders
- Russian Science Foundation