Endothelial Cell pY397-FAK Expression Predicts the Risk of Breast Cancer Recurrences after Radiotherapy in the SweBCG91-RT Cohort
Within the first 5 years following BCS, patients with low EC_pY397-FAK expression derive greater benefit from RT than patients with high EC_pY397-FAK expression. However, without RT, low EC_pY397-FAK expression is associated with a higher risk of recurrence.
Authors
- Rebecca J.G. Drake (ORCID: https://orcid.org/0000-0002-1206-6053)
- Kairbaan Hodivala‐Dilke (ORCID: https://orcid.org/0000-0002-2859-749X)
- Axel Stenmark Tullberg (ORCID: https://orcid.org/0000-0002-3652-3706)
- Emma Niméus (ORCID: https://orcid.org/0000-0003-0262-9083)
- Fredrika Killander (ORCID: https://orcid.org/0000-0001-6266-0459)
- Jennifer R. McGuinness (ORCID: https://orcid.org/0000-0001-6041-6292)
- Erik Holmberg (ORCID: https://orcid.org/0000-0001-5107-4550)
- Per Karlsson (ORCID: https://orcid.org/0000-0003-4841-2672)
- Amalia H. Landén (ORCID: https://orcid.org/0009-0001-9047-4482)
- Alexander Jordan
Institutions
- Queen Mary University of London (GB)
- Lund University (SE)
- Sahlgrenska University Hospital (SE)
- Region Västra Götaland (SE)
- Skåne University Hospital (SE)
- Pancreatic Cancer Research Fund (GB)
- University of Gothenburg (SE)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-2939
- Citations
- 3
- Primary Topic
- Angiogenesis and VEGF in Cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Queen Mary University of London
- Barts Charity
- Cancer Research UK
- Cancerfonden
- Vetenskapsrådet
- Medical Research Council