Engineered Nanotopographies Induce Transient Openings in the Nuclear Membrane (Adv. Funct. Mater. 6/2025)
Engineered Nanotopographies In article number 2410035, Zeinab Jahed and co-workers show that engineered nanotopographies create transient openings in the nuclear membrane without direct penetration into the cell. The study reveals how these membrane disruptions, caused by nanoscale curvature, are naturally repaired via ESCRT-mediated mechanisms. These findings offer new opportunities in biomedical technology and targeted therapies by allowing manipulation of the nuclear membrane, with potential applications in nuclear-targeted delivery and intracellular sensing. Art by the team of INMYWORK Studio.
Authors
- Colleen A. McHugh (ORCID: https://orcid.org/0000-0001-6008-2640)
- Keivan Rahmani (ORCID: https://orcid.org/0000-0001-6289-540X)
- Johannes Schöneberg (ORCID: https://orcid.org/0000-0001-7083-1828)
- Einollah Sarikhani (ORCID: https://orcid.org/0000-0002-7841-5244)
- Lingyan Shi (ORCID: https://orcid.org/0000-0003-1373-3206)
- Zeinab Jahed (ORCID: https://orcid.org/0000-0002-0139-3219)
- Dhivya Pushpa Meganathan (ORCID: https://orcid.org/0009-0009-1162-5659)
- Ryan Hosseini
- Leah Sadr
- Zhi Li (ORCID: https://orcid.org/0000-0003-4062-5358)
- Shivani Shukla
- Hamed Naghsh‐Nilchi (ORCID: https://orcid.org/0000-0001-6749-2474)
- Adarsh Balaji (ORCID: https://orcid.org/0009-0007-3295-9936)
- Gillian McMahon
- Diether Visda
- S.-Y. Chen
- Vrund Patel (ORCID: https://orcid.org/0000-0003-1711-0487)
Institutions
- University of California San Diego (US)
- La Jolla Bioengineering Institute (US)
Publication Details
- Journal
- Advanced Functional Materials
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/adfm.202570031
- Primary Topic
- Force Microscopy Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00