Modulation of the thiol redox proteome by sugarcane ash-derived silica nanoparticles: insights into chronic kidney disease of unknown etiology
Results suggest that PCT cell exposure to SAD SiNPs could promote glycolytic and fibrotic shifts consistent with CKDu pathology via oxidative stress-mediated disruption of redox signaling pathways.
Authors
- Arthur Stem (ORCID: https://orcid.org/0000-0002-2807-0655)
- Richard J. Johnson (ORCID: https://orcid.org/0000-0003-3312-8193)
- Peter S. Harris (ORCID: https://orcid.org/0000-0003-0324-0862)
- Richard Reisdorph
- Matthew Gibb
- Cole R. Michel (ORCID: https://orcid.org/0000-0002-9058-7495)
- Kristofer S. Fritz (ORCID: https://orcid.org/0000-0002-1499-6174)
- Carlos A. Roncal-Jiménez (ORCID: https://orcid.org/0000-0001-7512-7776)
- James R. Roede (ORCID: https://orcid.org/0000-0002-8425-6366)
- Keegan L. Rogers (ORCID: https://orcid.org/0000-0001-6069-0689)
- Jared M. Brown (ORCID: https://orcid.org/0000-0002-0400-1129)
Institutions
- University of Colorado Anschutz Medical Campus (US)
Publication Details
- Journal
- Particle and Fibre Toxicology
- Published
- 2025-02-06
- DOI
- https://doi.org/10.1186/s12989-025-00619-8
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Environmental Health Sciences