Oncometabolite D-2HG drives tumor metastasis and protumoral macrophage polarization by targeting FTO/m6A/ANGPTL4/integrin axis in triple-negative breast cancer
Our study unveils a previously unrecognized role for D-2HG-mediated RNA modification in TNBC progression and targeting the D-2HG/FTO/m<sup>6</sup>A/ANGPTL4/integrin axis can serve as a promising therapeutic target for TNBC patients.
Authors
- Qifeng Yang (ORCID: https://orcid.org/0000-0003-0576-8513)
- Jie Hao (ORCID: https://orcid.org/0009-0002-7208-7443)
- Yinqiao He
- Yiwei Liu (ORCID: https://orcid.org/0000-0001-9885-6429)
- Ning Zhang (ORCID: https://orcid.org/0000-0002-6430-4236)
- Lijuan Wang (ORCID: https://orcid.org/0000-0002-9797-0753)
- Bing Chen (ORCID: https://orcid.org/0000-0002-3597-7861)
- Dan Luo (ORCID: https://orcid.org/0000-0001-6074-1298)
- Wenjing Zhao (ORCID: https://orcid.org/0000-0002-6282-6356)
- Yidong Liu (ORCID: https://orcid.org/0000-0002-4631-0771)
- Chao Gao
- Siyue Zhang (ORCID: https://orcid.org/0000-0003-2723-9428)
- Tong Wan
Institutions
- Shandong University (CN)
- Biology Institute of Shandong Academy of Sciences (CN)
- Qilu Hospital of Shandong University (CN)
- State Key Laboratory of Microbial Technology
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-02-06
- DOI
- https://doi.org/10.1186/s13046-025-03282-1
- Citations
- 11
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 8.87
Funders
- Shandong University
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- Recruitment Program of Global Experts
- National Key Research and Development Program of China
- National Ten Thousand Talent Program