Mannitol‐Based CO Surrogate for Palladium‐Catalyzed Alkoxycarbonylation

Abstract Carbonylative transformation is already been accepted as a powerful toolbox in synthetic chemistry. However, the manipulation of toxic and smell‐less carbon monoxide gas lagged it from wide range applications. Hence the developing of new and efficient CO surrogates become an attractive topic. Herein, we developed a novel mannitol‐based carbon monoxide surrogate with an enhanced carbon monoxide loading capacity compared to known organic carbon monoxide surrogates. We successfully used it in the palladium‐catalyzed alkoxycarbonylation of aryl bromides with phenols only 0.5 equivalent of it required. This newly designed carbon monoxide surrogate offers additional possibility for further development in CO chemistry.