Development of an atherosclerosis rabbit model to evaluate the hemodynamic impact of extracorporeal circulation
A rabbit model with high aortic calcific plaque burden-diet-induced with no implicit need of an additional intimal injury by an intraaortic balloon insufflation due to comparable outcome-exhibiting multiple pathophysiological aspects of human atherosclerosis has been designed and thoroughly characterized. It is suitable for use in future studies on the interaction between atherosclerotic plaques and the arterial blood flow under ECC.
Authors
- Hug Aubin (ORCID: https://orcid.org/0000-0001-9289-8927)
- Johanna Buschmann (ORCID: https://orcid.org/0000-0001-7919-7448)
- Ali Karakaş
- S. Reimers
- A Assmann
- Artur Lichtenberg (ORCID: https://orcid.org/0000-0001-8580-6369)
- Elvira Weber (ORCID: https://orcid.org/0000-0002-0100-923X)
- Alexander Assmann
Institutions
- Düsseldorf University Hospital (DE)
- Heinrich Heine University Düsseldorf (DE)
Publication Details
- Journal
- Animal Models and Experimental Medicine
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1002/ame2.12556
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Herzstiftung