Efficient biosynthesis of β-caryophyllene by engineered Yarrowia lipolytica
A biosynthetic pathway of β-caryophyllene was firstly investigated in Y. lipolytica in this study. Through the modulation of key enzyme expression, we successfully demonstrated an improvement in β-caryophyllene production. This strategy suggests its potential extension to studies involving the microbial production of various industrially relevant terpenes.
Authors
- Lucie Studená (ORCID: https://orcid.org/0000-0001-9303-1778)
- A. Botes
- Young Kyoung Park (ORCID: https://orcid.org/0000-0003-1989-7498)
- Jean‐Marc Nicaud (ORCID: https://orcid.org/0000-0002-6679-972X)
- Piotr Hapeta (ORCID: https://orcid.org/0000-0002-0777-0986)
- Rodrigo Ledesma‐Amaro (ORCID: https://orcid.org/0000-0003-2631-5898)
- David Bell (ORCID: https://orcid.org/0000-0002-1107-0157)
- Ramdane Haddouche
- Pablo Torres-Montero (ORCID: https://orcid.org/0000-0002-5970-1907)
- José L. Martínez (ORCID: https://orcid.org/0000-0002-4490-8534)
Institutions
- AgroParisTech (FR)
- Université Paris-Saclay (FR)
- Microbiologie de l’alimentation au service de la santé (FR)
- UK Research and Innovation (GB)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Imperial College London (GB)
- Technical University of Denmark (DK)
Publication Details
- Journal
- Microbial Cell Factories
- Published
- 2025-02-06
- DOI
- https://doi.org/10.1186/s12934-025-02660-w
- Citations
- 3
- Primary Topic
- Microbial Metabolic Engineering and Bioproduction
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- UK Research and Innovation
- Imperial College London
- European Commission
- Engineering and Physical Sciences Research Council
- Biotechnology and Biological Sciences Research Council
- HORIZON EUROPE European Innovation Council