Collective Total Synthesis of Aculeatin A, B, D, E, and F
A collective convergent approach for the enantioselective total synthesis of aculeatins A, B, D, E, and F is presented, featuring [3 + 2]-cycloaddition, iron-mediated reductive N-O bond cleavage, and cascade spirocyclization. Moreover, this short six-step strategy is supplemented in synthesizing unnatural analogs of aculeatins such as 6-<i>epi</i>-aculeatin D, 6-<i>epi</i>-aculeatin E, and 6-<i>epi</i>-aculeatin F.
Authors
- Parthasarathi Subramanian (ORCID: https://orcid.org/0000-0002-0896-6147)
- Manoj Kumar (ORCID: https://orcid.org/0000-0002-5799-8284)
Institutions
- Indian Institute of Technology Kanpur (IN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1021/acs.joc.4c03024
- Citations
- 1
- Primary Topic
- Chemical synthesis and alkaloids
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Ministry of Education, India
- Science and Engineering Research Board