Real‐world interpatient variability in the pharmacokinetics of levetiracetam
LEV clearance is an effective predictor of serum concentration. CrCL was a significant covariate influencing LEV clearance, and BSA was found to influence the volume of distribution. Further studies are needed to determine the effect of body weight descriptors on LEV clearance and, ultimately, outcomes.
Authors
- Luigi Brunetti (ORCID: https://orcid.org/0000-0003-0565-6167)
- Leonid Kagan (ORCID: https://orcid.org/0000-0003-3863-4757)
- Mary Wagner (ORCID: https://orcid.org/0000-0002-3441-504X)
- Alina Chykharivska
Institutions
- Rutgers, The State University of New Jersey (US)
- Somerset Medical Center (US)
Publication Details
- Journal
- Fundamental and Clinical Pharmacology
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1111/fcp.13059
- Citations
- 3
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.41