Impact of porous lung substitute on linear energy transfer (LET) assessed via Monte Carlo simulation and CR‐39 measurement with a carbon‐ion beam
Porous lung-equivalent structures significantly affect LET<sub>d</sub> distributions in carbon-ion therapy, as confirmed by both CR-39 measurements and MC simulations. IMPT with LET<sub>d</sub> optimization may be more impacted by porous structures in terms of median and minimum LET<sub>d</sub> values within the target. The Gaussian convolution function shows promise for enhancing LET<sub>d</sub> calculation accuracy, but further validation in anatomically complex models is needed to assess its clinical feasibility.
Authors
- Shiyan Yang (ORCID: https://orcid.org/0000-0003-0013-2911)
- Jingfang Zhao (ORCID: https://orcid.org/0000-0002-2374-2678)
- Michael F. Moyers
- Weiwei Wang (ORCID: https://orcid.org/0000-0002-8993-8411)
- Zhiyuan Yang (ORCID: https://orcid.org/0000-0003-1738-6096)
- Bo Chen (ORCID: https://orcid.org/0000-0001-9646-1474)
Institutions
- Fudan University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Institute of Modern Physics (CN)
- Center for High Pressure Science & Technology Advanced Research (CN)
Publication Details
- Journal
- Medical Physics
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1002/mp.17671
- Citations
- 2
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- Shanghai Pudong New Area Health Commission