Spatial Proteomics by Parallel Accumulation‐Serial Fragmentation Supported MALDI MS/MS Imaging: A First Glance Into Multiplexed and Spatial Peptide Identification
In this study, we present a novel pipeline, based on iprm-PASEF, that allows the multiplexed and spatial identification of tryptic peptides in MALDI imaging. Hence, it marks a first step towards the integration of MALDI imaging into the emerging field of spatial proteomics.
Authors
- Jannik Witte
- Nadine Meier
- Mujia Li
- Lotte Studsgaard Meyer
- Melanie Christine Föll (ORCID: https://orcid.org/0000-0002-1887-7543)
- Oliver Schilling (ORCID: https://orcid.org/0000-0002-8466-3324)
- Adrianna Seredynska
- Julia Schueler
- Maximilian Maldacker
Institutions
- University of Freiburg (DE)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Medical Center Freiburg (DE)
- Charles River Laboratories (Germany) (DE)
Publication Details
- Journal
- Rapid Communications in Mass Spectrometry
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1002/rcm.10006
- Citations
- 13
- Primary Topic
- Mass Spectrometry Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 9.83
Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung