A pan-cancer analysis of homeobox family: expression characteristics and latent significance in prognosis and immune microenvironment
Many HOX genes may act as both oncogenes and tumor suppressor genes, necessitating precision medicine based on specific cancers. The HOX gene family plays a crucial role in the development of certain cancers, and their expression patterns are closely related to cancer prognosis and the tumor microenvironment (TME), which may affect cancer prognosis and response to immunotherapy. Compounds that are negatively correlated with the expression levels of the HOX family in various cancers, such as HDAC inhibitors, are potential anti-cancer drugs. HOXB7 and HOXC6 may serve as potential targets for cancer treatment and the development of targeted compounds in the future.
Authors
- Zhiyong Jason Ren (ORCID: https://orcid.org/0000-0001-7606-0331)
- Yan Wu (ORCID: https://orcid.org/0000-0002-3745-4183)
- Ziyi Shen
- Chunpeng Wan (ORCID: https://orcid.org/0000-0001-6892-016X)
- Lei Sun (ORCID: https://orcid.org/0000-0001-9599-608X)
- Wei Gu (ORCID: https://orcid.org/0000-0002-7221-3887)
- Qinfang Miao (ORCID: https://orcid.org/0009-0003-8145-699X)
- Tingdong Yan (ORCID: https://orcid.org/0000-0002-5193-022X)
- Yi Cai (ORCID: https://orcid.org/0000-0003-2296-222X)
- Y Wang (ORCID: https://orcid.org/0009-0001-0602-4041)
- Wei Liu (ORCID: https://orcid.org/0000-0001-8920-1172)
- Jia Jia (ORCID: https://orcid.org/0000-0001-5711-2562)
- Jie Gao (ORCID: https://orcid.org/0000-0002-5265-1652)
- Xiaomeng Hu (ORCID: https://orcid.org/0000-0003-3273-4335)
Institutions
- Shanghai University (CN)
- Capital Medical University (CN)
- National Medical Products Administration (CN)
- Huzhou Normal University (CN)
- Yili Normal University (CN)
- Beijing Ditan Hospital (CN)
- Jiangxi Agricultural University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-02-06
- DOI
- https://doi.org/10.3389/fonc.2025.1521652
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52