High and low dose radiotherapy combined with ICIs for MSS colorectal cancer patients with liver metastases: a phase I study (HaRyPOT)
In summary, this is the first clinical trial demonstrating the safety and immunogenic activity of combined high and low dose radiotherapy with ICIs in MSS colorectal cancer liver metastases (CRLMs). The combination therapy stimulated the immune response and altered the tumour microenvironment, warranting further exploration in the future.
Authors
- Yangfan Ye
- Yuxuan Ding
- Liangjun Zhu
- Jiayi Shen (ORCID: https://orcid.org/0000-0002-7022-6940)
- Chang Guo (ORCID: https://orcid.org/0000-0002-9924-8297)
- X. T. He (ORCID: https://orcid.org/0000-0002-7033-7640)
- Lijun Wang (ORCID: https://orcid.org/0000-0001-9084-2962)
- Yong Feng (ORCID: https://orcid.org/0000-0001-5523-6860)
Institutions
- Jiangsu Cancer Hospital (CN)
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-02-06
- DOI
- https://doi.org/10.3389/fonc.2025.1503517
- Citations
- 1
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.32
Funders
- Jiangsu Commission of Health