IL-6 Inhibitors and TNF Inhibitors
Interleukin-6 inhibitors (IL-6i) are commonly used in patients with rheumatoid arthritis to reduce inflammation from chronically increased IL-6. IL-6 levels increase transiently following exercise, exerting numerous positive effects. This study examined if beneficial exercise-induced cardiac adaptations were attenuated in patients with rheumatoid arthritis in concomitant IL-6i treatment compared with tumor necrosis factor inhibitors. Compared with control, we found that the tumor necrosis factor inhibitor-treated group, but not the IL-6i group, had a significant increase in left ventricular mass following 12 weeks of supervised exercise. However, the interaction effect of treatment modalities on exercise-induced cardiac adaptations was insignificant. (Exercise-induced Cardiac Adaptions in Rheumatoid Arthritis Patients During IL-6 vs TNF Antibody Therapy; NCT05215509).
Authors
- Iben Elmerdahl Rasmussen (ORCID: https://orcid.org/0000-0001-6349-0308)
- Simon Jønck (ORCID: https://orcid.org/0000-0001-6828-9398)
- Robin Christensen (ORCID: https://orcid.org/0000-0002-6600-0631)
- Peter Godsk Jørgensen (ORCID: https://orcid.org/0000-0002-1217-8944)
- Lars Køber (ORCID: https://orcid.org/0000-0002-6635-1466)
- Mathilde Løk (ORCID: https://orcid.org/0000-0002-6750-5156)
- Morten Asp Vonsild Lund (ORCID: https://orcid.org/0000-0002-2711-1259)
- Niels Grove Vejlstrup (ORCID: https://orcid.org/0000-0002-5362-8593)
- Ronan M. G. Berg (ORCID: https://orcid.org/0000-0002-5757-9506)
- Bente Klarlund Pedersen (ORCID: https://orcid.org/0000-0001-6508-6288)
- Helga Ellingsgaard (ORCID: https://orcid.org/0000-0002-9105-5247)
- Lene Dreyer (ORCID: https://orcid.org/0000-0002-5156-2922)
- Søren Jacobsen (ORCID: https://orcid.org/0000-0002-5654-4993)
- Pil Højgaard (ORCID: https://orcid.org/0000-0002-8046-263X)
- Malte Lund Adamsen (ORCID: https://orcid.org/0000-0002-0394-0722)
- Anna Agnes Lytzen (ORCID: https://orcid.org/0009-0000-0553-9783)
- Regitse Højgaard Christensen
Institutions
- University of Copenhagen (DK)
- Aalborg University Hospital (DK)
- Copenhagen University Hospital (DK)
- Gentofte Hospital (DK)
- Rigshospitalet (DK)
Publication Details
- Journal
- JACC Basic to Translational Science
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1016/j.jacbts.2024.11.010
- Citations
- 4
- Primary Topic
- Exercise and Physiological Responses
- Type
- article
- Field-Weighted Citation Impact
- 4.10