TGF-β induces cholesterol accumulation to regulate the secretion of tumor-derived extracellular vesicles
Hence, we delineated a novel signaling cascade that leads to high rates of EV generation by cancer cells in response to TGF-β, with cholesterol being a key intermediate step in this mechanism.
Authors
- Konstantina Psatha
- Michalis Aivaliotis (ORCID: https://orcid.org/0000-0003-1173-7705)
- Chrysoula Tsirigoti (ORCID: https://orcid.org/0000-0001-6554-738X)
- Dimitris Kletsas (ORCID: https://orcid.org/0000-0002-9828-3963)
- Aristidis Moustakas (ORCID: https://orcid.org/0000-0001-9131-3827)
- Dorival Mendes Rodrigues‐Junior (ORCID: https://orcid.org/0000-0002-8861-9240)
- Carl-Henrik Heldin
Institutions
- Uppsala University (SE)
- National Centre of Scientific Research "Demokritos" (GR)
- Aristotle University of Thessaloniki (GR)
- Science for Life Laboratory (SE)
- AstraZeneca (Australia) (AU)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-02-06
- DOI
- https://doi.org/10.1186/s13046-025-03291-0
- Citations
- 11
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 8.87
Funders
- Uppsala Universitet