Aldh2 and the tumor suppressor Trp53 play important roles in alcohol-induced squamous field cancerization

This study provides for the first time the evidence that alcohol drinking, Aldh2 dysfunction and Trp53 loss cooperate in squamous field cancerization. Alcohol consumption volume affects the SCCs development, even in the same genotype.

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Publication Details

Journal
Journal of Gastroenterology
Published
2025-02-06
DOI
https://doi.org/10.1007/s00535-024-02210-y
Citations
2
Primary Topic
Cancer-related Molecular Pathways
Type
article
Field-Weighted Citation Impact
2.09

Funders

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article

Aldh2 and the tumor suppressor Trp53 play important roles in alcohol-induced squamous field cancerization

Seiji Naganuma, Yu Uneno, Yosuke Mitani, Trang H. Nguyen Vu et al.
2 citations
Journal of Gastroenterology
Cancer-related Molecular Pathways
2.09
article

Aldh2 and the tumor suppressor Trp53 play important roles in alcohol-induced squamous field cancerization

Seiji Naganuma, Yu Uneno, Yosuke Mitani, Trang H. Nguyen Vu, Masashi Tamaoki, Samuel Flashner, Manabu Muto, Tomoki Saito, Shinya Ohashi, Masataka Shimonosono, Yukie Nakai, Yuki Kondo, Tomonari Matsuda, Tomohiro Kondo, Kenshiro Hirohashi, Hiroshi Nakagawa, Shigeki Kataoka, Akira Yokoyama, Osamu Kikuchi, Chikatoshi Katada, Tomohiko Sunami, Yoshihiro Yamamoto, Junichi Matsubara, Atsushi Yamada, Kohei Oryu
article en
2 citations

Abstract

This study provides for the first time the evidence that alcohol drinking, Aldh2 dysfunction and Trp53 loss cooperate in squamous field cancerization. Alcohol consumption volume affects the SCCs development, even in the same genotype.

Journal of GastroenterologyVol. 60(5)
Kyoto University (JP), Columbia University Irving Medical Center (US), Kyoto University Hospital (JP), Kitasato University (JP), Kochi Gakuen College (JP)
Foundation for the National Institutes of Health, University of Occupational and Environmental Health, Princess Takamatsu Cancer Research Fund, Irving Medical Center, Columbia University, Japan Society for the Promotion of Science
Good health and well-being
Openalex Percentile: Top 14%
Cancer-related Molecular Pathways
2.09
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