Aldh2 and the tumor suppressor Trp53 play important roles in alcohol-induced squamous field cancerization
This study provides for the first time the evidence that alcohol drinking, Aldh2 dysfunction and Trp53 loss cooperate in squamous field cancerization. Alcohol consumption volume affects the SCCs development, even in the same genotype.
Authors
- Seiji Naganuma
- Yu Uneno (ORCID: https://orcid.org/0000-0002-0322-8815)
- Yosuke Mitani (ORCID: https://orcid.org/0000-0003-1603-0004)
- Trang H. Nguyen Vu
- Masashi Tamaoki (ORCID: https://orcid.org/0000-0002-4221-3448)
- Samuel Flashner (ORCID: https://orcid.org/0000-0001-9796-0515)
- Manabu Muto (ORCID: https://orcid.org/0000-0002-3127-8203)
- Tomoki Saito (ORCID: https://orcid.org/0000-0002-1904-6055)
- Shinya Ohashi (ORCID: https://orcid.org/0000-0003-1776-4309)
- Masataka Shimonosono (ORCID: https://orcid.org/0000-0002-9857-3338)
- Yukie Nakai (ORCID: https://orcid.org/0000-0003-2876-7740)
- Yuki Kondo
- Tomonari Matsuda (ORCID: https://orcid.org/0000-0002-6177-1066)
- Tomohiro Kondo (ORCID: https://orcid.org/0000-0001-5102-2654)
- Kenshiro Hirohashi (ORCID: https://orcid.org/0000-0001-9803-9920)
- Hiroshi Nakagawa (ORCID: https://orcid.org/0000-0001-7330-4863)
- Shigeki Kataoka (ORCID: https://orcid.org/0000-0002-1072-8367)
- Akira Yokoyama (ORCID: https://orcid.org/0000-0003-4636-5032)
- Osamu Kikuchi (ORCID: https://orcid.org/0000-0001-5012-5897)
- Chikatoshi Katada (ORCID: https://orcid.org/0000-0002-2713-4661)
- Tomohiko Sunami
- Yoshihiro Yamamoto (ORCID: https://orcid.org/0000-0002-1143-5830)
- Junichi Matsubara (ORCID: https://orcid.org/0000-0003-0116-5133)
- Atsushi Yamada
- Kohei Oryu
Institutions
- Kyoto University (JP)
- Columbia University Irving Medical Center (US)
- Kyoto University Hospital (JP)
- Kitasato University (JP)
- Kochi Gakuen College (JP)
Publication Details
- Journal
- Journal of Gastroenterology
- Published
- 2025-02-06
- DOI
- https://doi.org/10.1007/s00535-024-02210-y
- Citations
- 2
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- Foundation for the National Institutes of Health
- University of Occupational and Environmental Health
- Princess Takamatsu Cancer Research Fund
- Irving Medical Center, Columbia University
- Japan Society for the Promotion of Science