Cell‐free epigenomes enhanced fragmentomics‐based model for early detection of lung cancer
Our study elucidated the regulatory relationships between epigenetic modifications and their effects on fragmentomic features. Identifying epigenetically regulated genes provided a critical foundation for developing the cfDNA fragmentomics-based machine learning model. The model demonstrated exceptional clinical performance, highlighting its substantial potential for translational application in clinical practice.
Authors
- Sibo Zhu (ORCID: https://orcid.org/0000-0003-4800-8987)
- Zhicheng Huang (ORCID: https://orcid.org/0000-0003-0399-9668)
- Daoyun Wang
- Tiantian Gu (ORCID: https://orcid.org/0000-0002-4430-9320)
- Liyang Song (ORCID: https://orcid.org/0009-0000-9676-5427)
- Bowen Li (ORCID: https://orcid.org/0000-0002-4295-916X)
- Chao Guo (ORCID: https://orcid.org/0000-0003-3729-4594)
- Haoxuan Jin (ORCID: https://orcid.org/0000-0003-0828-512X)
- Shanqing Li
- Haoxiang Xu (ORCID: https://orcid.org/0000-0002-5047-5341)
- Zhibo Zheng (ORCID: https://orcid.org/0000-0002-3072-7089)
- Shuai Hong
- Qiang Guo (ORCID: https://orcid.org/0009-0002-0644-350X)
- Zhe Feng (ORCID: https://orcid.org/0000-0002-7851-8999)
- Shiyuan Tong (ORCID: https://orcid.org/0000-0002-7899-5728)
- Jinlei Song
- Yadong Wang (ORCID: https://orcid.org/0000-0003-3919-1759)
- Yuan Xu (ORCID: https://orcid.org/0000-0002-2836-5293)
- Hongda Chen (ORCID: https://orcid.org/0000-0001-6171-1162)
- Haochen Li (ORCID: https://orcid.org/0000-0003-0104-8818)
- Naixin Liang (ORCID: https://orcid.org/0000-0001-7995-4226)
- Fei Zhao (ORCID: https://orcid.org/0009-0003-6583-6423)
- Zhongxing Bing
- Xiaoqing Yu (ORCID: https://orcid.org/0009-0005-2540-0945)
- Hefei Li (ORCID: https://orcid.org/0000-0003-1081-6604)
- Chen Meng (ORCID: https://orcid.org/0000-0002-0478-4282)
- Bin Zhou (ORCID: https://orcid.org/0000-0002-8198-5563)
- Jianhong Shi (ORCID: https://orcid.org/0000-0003-2232-1000)
- Xueguang Sun (ORCID: https://orcid.org/0009-0005-5802-3189)
- Yang Song (ORCID: https://orcid.org/0000-0003-3029-7629)
- Jing Liu (ORCID: https://orcid.org/0000-0001-9513-3591)
- Ka Luk Fung
- Haibo Wang
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Affiliated Hospital of Hebei University (CN)
- The Sixth People's Hospital of Shenyang (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/ctm2.70225
- Citations
- 12
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 11.23
Funders
- Peking Union Medical College Hospital