CX3CR1+ age-associated CD4+ T cells contribute to synovial inflammation in late-onset rheumatoid arthritis
Our findings suggest that the immunopathogenesis of RA differs by age of onset, with CX3CR1<sup>+</sup> age-associated cytotoxic CD4<sup>+</sup> T cells playing a significant role in LORA. Additionally, the presence of a specific CX3CR1<sup>+</sup> T cell subset may be linked to treatment resistance.
Authors
- Shigetoshi Wakasugi
- Ryo Inukai
- Yuko Kaneko (ORCID: https://orcid.org/0000-0003-2646-5765)
- Keiko Yoshimoto (ORCID: https://orcid.org/0000-0002-6491-267X)
- Sho Ishigaki (ORCID: https://orcid.org/0009-0001-3100-9011)
- Koichi Saito (ORCID: https://orcid.org/0000-0001-6497-5286)
- Yasushi Kondo (ORCID: https://orcid.org/0000-0002-1566-2088)
- Mitsuhiro Akiyama (ORCID: https://orcid.org/0000-0001-5075-8977)
- Waleed Alshehri (ORCID: https://orcid.org/0000-0002-2925-0279)
- Yukihiko Matsuno
Institutions
- Keio University (JP)
- Keio University Hospital (JP)
Publication Details
- Journal
- Inflammation and Regeneration
- Published
- 2025-02-06
- DOI
- https://doi.org/10.1186/s41232-025-00367-4
- Citations
- 4
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 3.19
Funders
- Kowa Company
- Keio University
- Kowa Life Science Foundation
- Japan Society for the Promotion of Science