Silencing drug transporters in human primary muscle cells modulates atorvastatin pharmacokinetics: A pilot study
Silencing ABCC1, ABCC4 or ABCG2 expression alters accumulation of atorvastatin in myotubes, whereas the effect of silencing influx transporters depends on the expression of these transporters.
Authors
- Nadtha Panin
- Emilia Hoste
- Romano Terrasi
- Vincent Haufroid (ORCID: https://orcid.org/0000-0001-5040-9806)
- Giulio G. Muccioli (ORCID: https://orcid.org/0000-0002-1600-9259)
- Louise Deldicque (ORCID: https://orcid.org/0000-0003-3393-5278)
- Laure Elens (ORCID: https://orcid.org/0000-0002-0039-3583)
- Sébastien Pyr dit Ruys (ORCID: https://orcid.org/0000-0002-5449-1541)
- Adrien Paquot (ORCID: https://orcid.org/0000-0002-4784-3510)
- Maxime Lingurski
Institutions
- Cliniques Universitaires Saint-Luc (BE)
- UCLouvain (BE)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1111/bph.17449
- Citations
- 3
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- Fonds De La Recherche Scientifique - FNRS
- Fonds pour la Formation à la Recherche dans l’Industrie et dans l’Agriculture